2021 The 2nd ESSE conference was successfully held via Internet because of the COVID-19 spreading. Thanks for the support from all participants and committee members. Hope to meet you all next year in person.

Welcome message from Prof. Zissis Mamuris, Rector of the University of Thessaly, Greece. Opening Remarks from Prof. Dr. Vassilis C. Gerogiannis, University of Thessaly, Greece.

We have invited Prof. Eleni Stroulia, University of Alberta, Canada; Prof. Maria Virvou, University of Piraeus, Greece; Prof. Ioannis Stamelos, Aristotle University of Thessaloniki, Greece; Prof. Johan Debayle, MINES Saint-Etienne, France.

Conference Proceedings
ESSE 2021 ACM proceedings (ISBN: 978-1-4503-8506-0) has been included in ACM Digital Library, indexed by Scopus and Ei Compendex.

Winners of Best Oral Presentation of Sessions
Special congratulations extend to all these best oral presenters of every sessions.
A Lightweight Development of Outbreak Prevention Strategies Built on Formal Methods and xDSLs
Akram Idani, Univ. Grenoble Alpes, France
A Personalized Diagnostic Tool for Microbiome-related Morbidities
Olympia Giannou, University of Patras, Greece
Nozzle-to-Work Distance Measurement and Control in Wire Arc Additive Manufacturing
Raven Thomas Reisch
Siemens AG, Technical University of Munich, Germany